Usually the initial focus is on removing the need to engage in low-level infrastructure programming (and problems), e.g., by using some middleware instead of using raw sockets for distributed applications. And then add more if needed. I also tend to isolate the external tools from my business domain objects by means of interfaces and layering, so that I can change the tool if I have to with a minimal amount of pain. A positive side effect of this approach is that I generally end up with a smaller application that uses fewer external tools than originally forecast.
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